Ampule



May 15, 1928.

L. W. VON GANS AMPULE Filed Auz. 28. 19%

Patented May 15, 1928.

V``Ium'ral) ;s'rAvTExs PATENT OFFICE..

LUDWIG WILHELM wmV GANS, or oBERUnsEL, KEsTENHoH, GERMANY; AssI'GNoB To THE FIRM: YHARMAGANSH rHAnMAoEUTIsoHEs ms'rr'rur LUDWIG WIL- mam!! GANs -A.-G., or onnnunsnr., GERMANY, A sooIn'rY or GERMANY; i

` ANPULE.

Application ld August 28, 1926, Serial No. 182,273, and n Germany January 5,-1926.

My invention refers'to storage vessels for medicinal solutionsand. more especiallyito ampules filled with solutions of pharmaceutical `preparations forvsubcutaneous and intramuscular injections. lt is an object of `my invention to provide an ampule or liquid container in whlch can be stored different components,lsuch as two liquids or a liquid and a'solid compound, which when mixed would soon be subject to decomposition.

Theampule according to the present invention comprises an out-er container which ma consist of glass, porcelain or the like an forms the ampule proper, an inner container of the same or some other suitable material, and means such as a glass rod or the like extending through a packing, for instance astopper, into the outer container and holding theinner container insuch position that its upper, end is fixed above the level of the liquid stored within the outer lcontainer. This holding means may at the same time serve to close the opening of the inner container. If it is desired to mix the contents of the inner coutainer with the contents of the outer containexyfor instance if an linjection shall bev made, the holding means, for instance the rod, on being withdrawn from the stopper or, other device closing the outer container will release its hold on the inner container, whereby this latteris dropped in' the outer container and its contents allowedto mix with the contents of the outer container.`

In the drawings affixed to this specification and forming part thereof several forms of a composite container embodying my invention are illustrated by way of example, in Vertical cross-section.

Referring first to Fig. 1, a; is the outer container or ampule, b is its neck, a is a stopper made of cork, ebonite, porcelain,'or the like and tightly closing the neck opening, d is a glass or porcelain rod extending into the ampule a through an axial boring of the stopper. e is a small auxiliary container sus ended from the bottom end of rodd which extends into it and closes it. f is a broad rim forming part of the auxiliary container e and lying flush against the bottom face of the stopper. The ampule or main container a may hold a liquid g, the auxiliary container another liquid or a solid substance h. If it is desired to mix the contents the two containers, rod d ispulled upwards in the stopper boring, thereby disengaging the auxlllary container e which drops into the liquid g, emptying its contents into it. After the mixture or solution has thus been effected, it can'be withdrawn through the stopper boring by meansofa .syringeyor the like when the rod is with-` 'drawn altogether from the boring. i

`lIn the modification illustrated in'v 2 the ampule a? is closed by means of a stopper which may consist of non-elastic,material,

for instance hard rubbe1',.celluloid, glass, porcelain, Synthetic resin, or the like, an

The rod all` carrie's a pis-1 iliary container 81. A cap ;i engaging the ring of the neck prevents the withdrawal of the stopper 01 if the piston 'm is llifted by means of rod dl todisengage the auxiliary container el; The shoulder between the parts dl and m prevents the piston mfrom being pulled out altogether. In this modification the main container al husa separate .I

lateral opening n closed by a cap 0. After removal of this cap the solution or .mixture obtalned after the auxihary containeihas ,been disengaged from the piston caninbe withdrawn by means of a syringe or the like. y

In' the modification shown'in Fig. 3 the stopper 02 is held in the neck by a rubber tube oi' otherisoft packing as described with reference to Fig. 2. This stopper has a cylindrical boringv of, even diameter throughout for the passageof the rod dz, However, in this case the auxiliary container 82 is formed with a top portion 3/ lof greater diameter, which embraces the bottom part of the stopper 02. On the other hand rod al2 is formed at its bottom end with a flange g, the diameter of which is smaller than the enlargement 2/ and greater than the naru rower part 82 of the auxiliary vessel. As shown, the auxiliary container is here not suspended from the bottom part of the rod or piston, but from the stopper itself, and

liuo

the rod d serves for forcing it oif'its seat when pushed into the main container, the flange g at the same time serving to close the auxiliary container.

The modification illustrated in Fig. 4 resembles the one shown in Fig. 2 in that the boring of the stopper has different diaineters, a narrou' boring being provided fort'hel passage of the rod d, which carries a solid handle 8, While the pistonl is formedin two parts m1 and m2 of larger diameter displaceable' in cylindrical cavities ll and`` 12 of correspondingly different diameters. The auxiliary vessel 83 is suspended again from the bot'tom piston m2. A cap 7' gripping'the rim of the neck of the main container covers thestopper 03 and serves as a separate closure.

In the modification shown in F ig. 5, the stopper c* is fixed in the neck by means of a rubber tube or the like it, as described with reference to Fig. 2, and has a boring having two diameters, a smalier-one for the rod d* and a greater one` for the' piston' 'mt The piston is provided with soft rubber piston rings a and o and has suspended from its bottom end the auxiliary container 0*. In this case the rod cl4 and piston m4 as well as the stop er a* may be'made of metal and neverthe ess the piston rings will airtightly Seal the main container at. An elastici cap 'w serves for improving the sealing of the opening of container at, its form being such that the rod d* can be gripped and displaced without removing the cap.

I wish it tobeunderstood that do not desire to be limited' to the exact details of construction shown and described for obvious modifications will occur to a person skilled in theart.

I claim:

1. Ampule for storing pharmaceutical products comprising a main container, a packing in the opening of said main container, anl auxiliary container freely suspended by its neck in said main container near said packing, and' means displaceably extending. through said packing and adapted to positively disconnect said auxiliary container from its seat.

2. Ampule forV storing pharmaceutical products comprising a main container, a packing in theopening of said main contain'- er. holding means displaceably mounted in said packing, and an auxiliary container in said main container freely suspended by its neck from said holding means.

3. Ampule for storing pharinaceutical products comprising a' main container, a packing in the opening of said main container, holding means disl'ilacea'bly mounted in said packing and an auxiliary container in said main container frccly suspended by its neck from and closed by said holding means.

4. Ampule' for storing pharmaceutical products comprising a main container, a packing in the opening of said main' container, holding means displaceably mounted insaid packing, an auxiliary container in said main container freely suspended by' its neck from said holding means, and means for limiting the displacement of said holding means.

5. Ampule for storing pharmaceutical products comprising a main container', a packing in' the opening of said main container, a rod extending through said packing, and an auxiliary container mounted by its ncck on and closed by the'bottom end of said rod.

6. Ampule for storing pharmaceutical products cmnprising a main conta'iner, a packing in the opening of said main container, a piston movablel in a cylindrical boring of said packing and an auxiliary conta'iner mountcd by its neck on the bottom endof said piston.

7. Ampule for storing pharmaceutical products comprising a main container, a parking in the opening of said maincontainer, an auxiliary container freely Suspended by its neck in said main container near said packing, means displaceably extending through said packing and adapted to positively disconnect said auxiliary container from its seat, and means associated with said auxiliary containei'for preventing its being pulled intov the boring of said packing.

8; Ampule for storing pharmaceutical products coinprising a'main container, a packing in the opening of said maincontainer, an auxiliary container freely suspended by its neck insaid main container near said packing, means disphiceably extending through said packing and adapted to positively disconnect said auxiliary container from its seat, and a rim surrounding the neck of said auxiliary container.

In testimony whereof I afiix my signature.

LUDVVIG YVILHELM VON GAN IUO 

